Description

The proteolytic enzymes, trypsin and bromelain, Is a synergistic combination that exhibits anti-inflammatory, anti-edematous and antioxidant properties. The combination help in mitigating excessive inflammatory reactions and resulting impairment of the natural defense mechanism. 

TRYPSIN (Proteolytic enzymes)

• A proteolytic enzyme that modulates the inflammatory response useful in rheumatologic diseases.
• Trypsin  circulates  in  blood  stream  bound  to  alpha-1 antitrypsin  (α1-AT)  and  has  more  affinity  to  it  than plasmin, allowing more plasmin  to  be  available  for fibrinolysis.

(Note: Around 10% of an orally  administered trypsin dose ends up in the blood.)

• Helps in the management of burns – enhanced fibrinolysis, enhanced wound-healing and lowering of proinflammatory cytokines.

• BROMELAIN (Proteolytic enzymes /protein-digesting enzymes)

• Obtained from the pineapple plant has fibrinolytic, antithrombotic, and anti-inflammatory properties, which help in controlling the complications of burns.

• Stimulates the conversion of plasminogen to plasmin, resulting in increased fibrinolysis. Improves total symptom score, stiffness and physical function in osteoarthritis patients.

       

• Its fibrinolytic action aids in the reabsorption of edema into the blood circulation. Proven successful oral enzyme therapy for oral surgery patients.

• RUTOSIDE TRIHYDRATE (Flavonoid-3-o-glycosides)

• Rutoside aka vitamin P is a polyphenolic  bioflavonoid,  extracted  from natural  sources such  as  oranges, lemons,  grapes,  limes, berries,  and  peaches.

• Possesses pharmacological activities like antioxidant, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective and cardioprotective activities.

• Inhibits the transcription of proinflammatory factors, TNF-α,  IL-1,  IL-8, & TNF-α, macrophage migration inhibitory  factor (MIF), and chemotactic factors in activated macrophages.

COMBINATION

• This combination is suggested to have analgesic, anti-inflammatory, anti-edematous and antioxidant properties.

• The combination therapy is involved in,

• Favourable modulation of inflammatory mediators, 
• Enhancement of plasmin levels, 
• Reduced leukocyte migration to injury site and, 
• Suppression of the formation of reactive oxygen species.

• This combination therapy is a promising new treatment modality to reduce pain in Temporomandibular Joint Osteoarthritis because of anti-inflammatory and anti-oxidant effects.