To End the High Cholesterol Levels
COMPOSITION – Atorvastatin Calcium IP Eq. to Atorvastatin 20 mg (As pellets form) + Clopidogrel Bisulphate IP eq. to Clopidogrel 75 mg (As pellets form) Aspirin IP 75 mg (As enteric coated pellets)
- Drug class: HMG-CoA reductase inhibitors (statins)
- Atorvastatin is an appropriate first-line lipid-lowering therapy in numerous groups of patients at low to high risk of CHD.
- Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase by doing so, helps decrease cholesterol production in the liver.
- Atorvastatin also increases the number of LDL receptors on the surface of hepatic cells.
- Clopidogrel is a prodrug, which needs to be metabolized in the liver into active metabolites.
- Clopidogrel efficiently reduces ADP-induced platelet aggregation (a key phenomenon in atherosclerosis & CVD) and prolongs bleeding time and is a safe and efficacious antiplatelet drug.
- Drug Class: NSAIDs
- The most widely tested antiplatelet regimen was aspirin. The benefit of low-dose aspirin therapy for the secondary prevention of serious cardiovascular events is clear.
- Aspirin has long been the therapeutic foundation of the secondary prevention of CVD, to which contemporary drugs such as statins, and other antithrombotics have been added.
- Aspirin and clopidogrel are antiplatelet agents that display good antithrombotic activity.Clopidogrel in combination with aspirin is the current “gold standard” for reducing cardiovascular events.
- Clopidogrel plus aspirin can reduce the relative risk of adverse cardiovascular events by 20%, compared with aspirin alone.
- Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation. But, statin (Atorvastatin) quickly decreases thrombosis risk and inflammation, and these effects may balance the loss of clopidogrel efficacy.
Atorvastatin Calcium IP Eq. to Atorvastatin 20 mg (As pellets form) + Clopidogrel Bisulphate IP eq. to Clopidogrel 75 mg (As pellets form) Aspirin IP 75 mg (As enteric coated pellets)
- Acute & chronic coronary syndrome
- Thromboembolic stroke
- Recurrent ischemic stroke
- Myocardial infarction