ROSACT-A GOLD Capsules

Description

Rosuvastatin 

• Drug class: HMG-CoA reductase inhibitors (statins)

Rosuvastatin Calcium

• Rosuvastatin calcium is one of the most commonly prescribed HMG-CoA reductase inhibitors.
• Rosuvastatin reduces high sensitivity C reactive protein (hsCRP) which is a marker of inflammation and an independent cardiovascular risk predictor and other inflammatory markers. 
• Rosuvastatin inhibits platelet aggregation to leukocytes which inhibits the formation of clots in injured endothelium.
• Rosuvastatin is less likely to cause metabolic drug-to-drug interactions since it has limited metabolism by CYP isoenzymes.
• A large retrospective cohort study in America found that rosuvastatin produced the largest reduction in LDL-C, non-HDL-C, and triglycerides when compared with other statins like atorvastatin and pravastatin. 

Aspirin

• The most widely tested antiplatelet regimen was aspirin. The benefit of low-dose aspirin therapy for the secondary prevention of serious cardiovascular events is clear.

• Aspirin has long been the therapeutic foundation of the secondary prevention of CVD, to which contemporary drugs such as statins, and other antithrombotics have been added.

Clopidogrel 

• Clopidogrel is a prodrug, which needs to be metabolized in the liver into active metabolites.

• Clopidogrel efficiently reduces ADP-induced platelet aggregation (a key phenomenon in atherosclerosis & CVD) and prolongs bleeding time and is a safe and efficacious antiplatelet drug.