RECICARD-T Tablets

Description

Cilnidipine 

• Class of medications: Calcium blockers
• Centrally acting as dihydropyridine calcium antagonist, improves the ambulatory BP & HR profile by significant suppression of LVH in hypertensive CKD patients. 

• Reduce urinary proteinuria than amlodipine, in protein-uric and hypertensive patients treated with renin-angiotensin blockades. 

• Significantly decreases urinary albumin excretion without affecting serum creatinine concentration in hypertensive patients as compared to ACE inhibitor benazepril. 

Telmisartan

• Class of medications: Angiotensin II receptor antagonists
• Newer angiotensin receptor blocker, very useful for the management of patients with mild-to-moderate hypertension.

• An important alternative as the first-line treatment of hypertension. 

• Produces greater reductions in both systolic blood pressure (SBP) & diastolic blood pressure (DBP) when compared with losartan. 

• Exert its PPARgamma enhancing activity clinically in obese or overweight type 2 diabetic patients as compared to candesartan.

COMBINATION

• The combination therapy was more effective in reducing BP than either drug in monotherapy without affecting glucose homeostasis. 

• Combination therapy with Cilnidipine & Telmisartan is more effective than treatment with Cilnidipine & Telmisartan alone & exhibits additive protective effects on renal & cardiac organs. 

• Cilnidipine & telmisartan, synergistically decreased plasma aldosterone concentrations and pulse wave velocity for preventing vascular complications.