Description

Rabeprazole 

Drug Class: Proton pump inhibitors

• Rabeprazole sodium is a proton pump inhibitor widely used as an antiulcer drug. 

• Has the highest pKa (acid strength)of all PPIs, hence least stable at neutral pH, is more rapidly converted to inhibit the proton pump as compared to omeprazole, lansoprazole, or pantoprazole.

• In older parietal cells, rabeprazole can be as much as 10 times more potent that other proton pump inhibitors.

• Known to have a faster onset of action in patients with heartburn, hence may have efficacy as an on-demand or abortive therapeutic agent.

• It is used in the treatment of gastric ulcer, peptic ulcer, ulcerative gastroesophageal reflux disease, duodenal ulcer Zollinger-Ellison syndrome, and Helicobacter pylori eradication in combination with amoxicillin.

Levosulpiride

Drug Class: A prokinetic agent of the benzamide class.

• Levosulpiride is substituted benzamide antipsychotics. 
• It is an atypical antipsychotic agent that blocks the presynaptic dopaminergic D2 receptors. 
• Like its parent compound, levosulpiride shows antagonism at D3 and D2 receptors. 
• Used in the treatment of psychosis, anxiety disorder, premature ejaculation (not recommended in some countries), vertigo, and irritable bowel syndrome.