Description

Pantoprazole

Drug Class: Proton Pump Inhibitors 

• Pantoprazole is an FDA approved (2000) irreversible proton pump inhibitor (PPI) that reduces gastric acid secretion.

• Oral pantoprazole 20 or 40 mg/day was effective at healing and preventing non-steroidal anti-inflammatory drug (NSAID)-related ulcers.

• Intravenous pantoprazole was at least as effective as intravenous ranitidine in preventing ulcer rebleeding after endoscopic hemostasis.

• Oral and intravenous pantoprazole appear to be well tolerated in patients with acid-related disorders in short- and long-term trials. 

• An effective agent in the management of acid-related disorders; 
• – As a component of triple therapy for H. pylori eradication and 
• – As monotherapy for the healing of oesophagitis and maintenance of gastro-oesophageal reflux disease.

• Has shown similar efficacy to other PPIs and greater efficacy than histamine H(2)-antagonists.