Description

H.Pylori is a prevalent infection in India with as many as nearly 60% reporting positive for it. 

H. pylori infection and NSAID/aspirin use show a higher prevalence of Peptic ulcer disease and ulcer bleeding in the elderly.

H. pylori-positive NSAID users have an almost two-fold increased risk of peptic ulcer bleeding compared to NSAID users without H. pylori. 

So, triple drug therapy of a PPI + Clarithromycin + Amoxycillin is a safe approach.

• One-week triple therapy is a first-line anti-H. pylori treatment.¹
• Effective and well-tolerated therapeutic approach with H.Pylori eradication rate of 94%.
• Has a low rate of side effects & high rates of patient compliance.²
• Useful in elderly patients with dyspeptic symptoms or reflux diseases.³

Pantoprazole 

Drug Class: Proton Pump Inhibitors

• Selective PPI used in the treatment of stomach ulcers.
• GERD and other acidity-related disorders.
• Decreases the acid production in the stomach and helps promote healing of ulcers

Clarithromycin

Drug Class: Macrolide antibiotics

• An acid-stable, better absorbed & widely used component of anti-H pylori regimen.
• High antimicrobial activity & fewer gastrointestinal adverse effects.⁴

Amoxycillin

Drug Class: Penicillin-like antibiotics.

• In combination with clarithromycin treats ulcers caused by H.pylori infection.
• Inhibits the production of the bacterial cell wall.