Losartan Potassium

• Exerts long-term antihypertensive effects by blocking angiotensin II-induced physiological effects.
• Shows 89% efficacy as compared to enalapril maleate.
• Has beneficial effects albumin excretion rate, blood pressure and renal hemodynamics providing renoprotection in diabetic patients with chronic nephropathy.

Hydrochlorthiazide

• Hydrochlorothiazide drug is versatile and can be combined with many other antihypertensive agents without inducing interactions.
• Acts on the distal convoluted tubules and inhibits the sodium chloride co-transporter system. This action leads to a diuretic action that lowers blood pressure.

Combination

• Safely and significantly decreases systolic and diastolic BP and plasma B-type natriuretic peptide (BNP).