OSART-H Tablets

Description

Losartan Potassium

• Class of medication: ARBs
• Exerts long-term antihypertensive effects by blocking angiotensin II-induced physiological effects.
• Shows 89% efficacy as compared to enalapril maleate.

Hydrochlorthiazide 

• Class of medications: Diuretics
• Hydrochlorothiazide drug is versatile and can be combined with many other antihypertensive agents without inducing interactions.
• Acts on the distal convoluted tubules and inhibits the sodium chloride co-transporter system. This action leads to a diuretic action that lowers blood pressure.

Combination

• Safely and significantly decreases systolic and diastolic BP and plasma B-type natriuretic peptide (BNP).
• The losartan/thiazide combination therapy attenuated glomerular overload, indicating that this therapy may provide glomerular protection in patients with an elevated GFR without causing prolonged damage to renal function.