Omeprazole is a substituted benzimidazole derivative that markedly inhibits basal and stimulated gastric acid secretion.
It has a unique mode of action, irreversibly blocking the so-called proton pump of the parietal cell which is supposedly the terminal step in the acid secretory pathway.
Represents a pharmacologically unique antisecretory drug that,
effectively & rapidly heals peptic ulcers/ oesophagitis, and
reduces gastric acid hypersecretion in Zollinger-Ellison syndrome patients.
Omeprazole 20 mg mane is superior to ranitidine 150 mg b.i.d. in the short-term treatment of duodenal ulcers.
Effective & well tolerated in treating acute/chronic esophageal and peptic ulcers in children, also in those who had failed to respond to treatment with histamine2-receptor antagonists.
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