A Blend of Active Analgesics for a Cut-Above Treatment
COMPOSITION – Nimesulide 100 mg + Paracetamol IP 325 mg
Nimesulide (Sulphonanilides)
An anti-inflammatory drug with methane sulphonamide; a preferential COXII inhibitor.
It is a potent analgesic, antipyretic, and anti-inflammatory drug.
Paracetamol (Also known as Acetaminophen/ Aniline analgesic)
A centrally and peripherally acting non-opioid analgesic and antipyretic.
Unlike nimesulide, paracetamol is a nonselective COX inhibitor and is an effective analgesic and antipyretic, but a poor anti-inflammatory drug. Indian J Pharmacol 2010;42:354-7
COMBINATION
Paracetamol alone are more efficacious analgesics as compared to the combination of nimesulide and paracetamol.
But their combination on human subjects is necessary to assess the subjective degree of pain and appropriateness of the combination.
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