• Nimesulide (Sulphonanilides)

• An anti-inflammatory drug with methane sulphonamide; a preferential COXII inhibitor. 
• It is a potent analgesic, antipyretic, and anti-inflammatory drug.

• Paracetamol (Also known as Acetaminophen/ Aniline analgesic)

• A centrally and peripherally acting non-opioid analgesic and antipyretic.

• Unlike nimesulide, paracetamol is a nonselective COX inhibitor and is an effective analgesic and antipyretic, but a poor anti-inflammatory drug. Indian J Pharmacol 2010;42:354-7

COMBINATION

• Paracetamol alone are more efficacious analgesics as compared to the combination of nimesulide and paracetamol.

• But their combination on human subjects is necessary to assess the subjective degree of pain and appropriateness of the combination.