Both cyclooxygenase COX-1 and COX-2 in our body produce prostaglandins that promote inflammation, pain, and fever.

• However, only COX-1 produces prostaglandins that activate platelets and protect the stomach and intestinal lining.  The blockage of COX-1 in consequence causes the adverse effects of NSAIDs. 

• When the COX-1 enzyme is blocked, inflammation is reduced, but the protection of the lining of the stomach also is lost; this may lead to stomach upset as well as ulceration.

• And COX-2 is responsible for the most inflammatory symptoms, such as pain, edema, fever, and increase in vessel permeability. 

So the selective inhibitors of COX-2 would be much more safe drugs, compared with the classical NSAIDs in the treatment of inflammatory diseases.  

Nimesulide 

• Drug class: Sulphonanilide

• Not only inhibits more selectively the activity of COX-2 but also some other properties that increase its anti-inflammatory and analgesic function.

• Belongs to the new generation of NSAIDs, unique as it contains sulphonanilide group. 

• Nimesulide (unlike most other NSAIDs) in the recommended doses appears to be well tolerated in aspirin-sensitive asthmatic patients. 

• An effective and well-tolerated alternative to other NSAIDs for short-term treatment of pain and inflammation of osteoarthritis and various other causes. Drugs.

DOSAGE

• At the recommended dosage of 100 mg twice a day nimesulide is as effective an analgesic and anti-inflammatory agent as classical NSAIDs.