INTRIZ – PLUS Tablets

 In Allergic Cold & Congestion Ensure relief without compromising ALERTNESS

Levocetirizine HCl 5 mg + Phenylephrine HCl 5 mg + Paracetamol IP

Description

COMPOSITION:

Levocetirizine (Anti-histaminic)

  • Levocetirizine, the R-enantiomer of Cetirizine is a non-sedating, new generation antihistamine with a high affinity for and occupancy of the H1-receptor.
  • It blocks the effects of histamine, a key mediator of allergic inflammation, which causes runny nose, itching, sneezing, and watery eyes. 
  • It has abridged anti-cholinergic and anti-serotonin effects and therefore is singled out in patients with allergies since it does not over dry respiratory secretions.

Phenylephrine (Nasal decongestant)

  • Phenylephrine is a sympathomimetic primarily used as a systemic nasal decongestant. 
  • The mechanism by which decongestants bring off their action is by activation of postjunctional alpha 1-adrenergic receptors found on precapillary and post-capillary blood vessels of the nasal mucosa. 
  • Activation of these receptors by distinct binding of the sympathomimetic agent to the binding site of the receptor or by the enhanced release of norepinephrine leads to vasoconstriction.

(Note: Vasoconstriction leads to shrinkage of the tissue by decreasing blood flow through the nasal mucosa.)

Paracetamol (Antipyretic)

  • A non-steroidal anti-inflammatory drug, most commonly used centrally acting analgesic, and its use as an antipyretic to treat fever, headache, and body ache are ubiquitous. 
  • Paracetamol does not alter acid the base balance, depress respiration, or cause gastric irritation.

COMBINATION:

  • A fixed-dose combination of Paracetamol, Phenylephrine, and Levocetirizine is safe and effective in the treatment of Common Cold and Allergic Rhinitis in children.
  • >50% reduction in symptom score and the majority of patients had complete relief from the symptom.

Composition

Levocetirizine HCl 5 mg + Phenylephrine HCl 5 mg + Paracetamol IP

Indications

  1. Allergic cold 
  2. Allergic rhinitis
  3. Nasopharyngitis
  4. Bronchitis
  5. Bronchial asthma