- LOLA is an effective ammonia-lowering agent currently employed for the treatment of hepatic encephalopathy (HE).
- It stimulates both urea synthesis by residual hepatocytes and muscle glutamine synthesis together with putative hepatoprotective actions.
- Treatment of cirrhotic patients with LOLA limits ammonia-induced sarcopenia by improving muscle protein synthesis and function.
- It is conceivable that the antisarcopenic action of LOLA contributes to its efficacy for the treatment of HE in cirrhosis.
L-Ornithine, L-Aspartate 150 mg
- Hepatic encephalopathy
- Liver cirrhosis