The pathophysiological hallmark of OA is the focal destruction of articular cartilage, which results from increased degradation of cartilage matrix molecules including type II collagen (CII) and proteoglycans.
Antioxidant therapy represents a potential avenue to tackle the degenerative joint changes and pain in osteoarthritis.
- Glucosamine Sulphate (Amino sugar)
- Valuable candidate for the treatment of OA (osteoarthritis) in patients with metabolic syndrome, diabetes, or cardiovascular diseases.
- Glucosamine sulfate significantly inhibits collagen degradation by activated chondrocytes (cells found in cartilage tissue).
- Methyl Sulfonyl methane (Sulfa drugs)
- MSM in patients with OA of the knee, showed an improvement in pain and physical function.
- Used by the body to maintain and repair connective tissue.
- About 99% of calcium is stored in bones, serves as a building block for bone health.
- Vitamin E & Vitamin C
- Vitamin E is a potent antioxidant agent to retard the progression of osteoarthritis by ameliorating oxidative stress and inflammation of the joint.
- Vitamin C has a beneficial effect on bone metabolism.
- Supplementation of Vitamins C and E, alone and together decreases the osteoclast activity and prevents oxidative stress.
- Necessary for the normal metabolism of articular cartilage, can slow down its degeneration and also beneficial for articular cartilage repair.
- Manganese in combination with glucosamine and chondroitin
- Glucosamine-based combination supplement is likely to have a beneficial effect on pain and other symptoms associated with knee OA.