COMPOSITION: Cefoperazone 500 mg + Salbactum sodium 500 mg
Production of beta-lactamases is one of the oldest ways to overcome antimicrobial agents’ activity.
Beta-lactamases are enzymes hydrolyzing the beta-lactam nucleus of beta-lactam antibiotics by using two strategies: a nucleophilic attack of a serine residue or activating a water molecule via a Zn++.
Cefoperazone (Cephalosporin antibiotics)
- Cefoperazone is a third-generation cephalosporin with broad-spectrum antimicrobial activity against Gram-positive and Gram-negative organisms, including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp. (Fass et al., 1990
- It’s an antibiotic commonly used for prophylaxis of infection.
Sulbactam sodium (Beta-lactamase inhibitors)
- Salbactam is a class A, β-lactamase inhibitor with intrinsic whole-cell activity against certain bacterial species, including Acinetobacter baumannii.
- Although sulbactam is used clinically as a β-lactamase inhibitor, it also has inherent antibacterial activity against a limited number of bacterial species, including Neisseriagonorrhoeae, Bacteroides fragilis, and, fortuitously, Acinetobacter spp.
Cefoperazone + Salbactum sodium
- Effective and safe for the treatment of moderate-to-severe bacterial infections caused mainly by beta-lactamase-producing organisms.
- Found to be as useful as imipenem/cilastatin for treating patients with Acinetobacter bacteremia.
- Effective and safe for the treatment of respiratory tract infections caused by beta-lactamase-producing as well as beta-lactamase non-producing bacteria.
- Clinically useful antibiotics in the treatment of elderly patients with urinary tract infections.