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Invision Medi Science

Invision Medi Science

ACTIPRAZ-40 Tablets / Injections

Perfect Remedy for Active Ulcers

COMPOSITION: Esomeprazole Magnesium 40mg 

Esomeprazole

Drug Class: Proton-pump inhibitors

Mode of Action

  • Esomeprazole magnesium reduces gastric acid secretion by inhibiting gastric enzyme H+, K+-ATPase (the proton pump) which is responsible for acid secretion by the parietal cells of the stomach.

Pharmacokinetics

  • Absorption of esomeprazole in healthy subjects results in peak plasma levels occurring 1 to 2 hours after dosing. 
  • The systemic bioavailability is 64% after a single 40 mg dose and 89% after repeated once daily oral administration. 
  • Esomeprazole is 97% protein bound and optically stable in vivo, with negligible inversion to the other isomer.

Pharmacodynamics

  • Absorption of esomeprazole in healthy subjects results in peak plasma levels occurring 1 to 2 hours after dosing. 
  • The systemic bioavailability is 64% after a single 40 mg dose and 89% after repeated once daily oral administration. 
  • The apparent volume of distribution at a steady state in healthy subjects is around 0.22 L/kg body weight.

Contraindication

  • Esomeprazole magnesium is contraindicated in patients with known hypersensitivity to substituted benzimidazoles or any component of the formulation. 
  • Hypersensitivity reactions may include anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute interstitial nephritis, and urticaria.

Better compared to other PPI

  • Esomeprazole 40 mg provides more effective acid control than omeprazole in patients with symptoms of gastroesophageal reflux disease.