“A Promising Frontier for Amplified Treatment for Vitamin B12“

PRODUCT SYNOPSIS

Cobanerve-B12 is a nasal spray formulation designed to deliver Methylcobalamin (vitamin B12) through intranasal administration.

PHARMACOLOGICAL ACTION & BENEFITS

Methylcobalamin is an active synthetic form of vitamin B12, a B vitamin that is crucial for cellular metabolism, particularly for DNA synthesis, methylation, and mitochondrial metabolism.

Intranasal Administration of Nasal Cobanerve-B12 offers:

Enhanced Patient Compliance: Provides a sustained increase in baseline cobalamin concentrations, resulting in a steady increase in hemoglobin levels. Nasal vitamin B12 may be more effective in treating vitamin B12 deficiency in patients receiving metformin compared to oral methylcobalamin, according to studies.

Improved Absorption: Offers improved systemic absorption, avoidance of first-pass metabolism, and non-invasive delivery.

Reduced Discomfort: Easy administration and avoids drug complexation.

Cost-effective: Compared to intramuscular injections, intranasal administration of vitamin B12 appears to be a safe and effective option.

Safety: Intranasal application of vitamin B12 seems a safe and effective alternative to intramuscular injections. Minimizes potential for adverse systemic effects.

MECHANISM OF ACTION

The active form of vitamin B12 Methylcobalamin, helps in the synthesis of methionine and S-adenosylmethionine. It is required for the integrity of myelin, neuronal function, proper red blood cell formation, and DNA synthesis. The methylcobalamin nasal spray increases bloodstream levels through hydroxocobalamin absorption and contributes to the overall pool of vitamin B12 in the body.

Vitamin B12 is involved in the metabolism of fat and carbohydrates and is necessary for the synthesis of DNA, the production of red blood cells, and neurological function.

INDICATIONS

• Vitamin B12 Deficiency  due to malabsorption-related causes such as autoimmune gastritis (pernicious anemia), celiac disease, inflammatory bowel disease, surgical gastrectomy, gastric bypass, and ileal resection.
• Vitamin B12 deficiency induced as a result of nutritional habits (strict vegans, breastfed infants born to vegan mothers with reduced dietary intake of animal products), drug interference (long-term metformin use).

CONTRAINDICATIONS

Not recommended to use if you have cold or runny nose.

SIDE EFFECTS/ ADVERSE REACTIONS

No severe side effects were reported. Sometimes mild, non-serious treatment-emergent adverse events like nasal congestion may occur, which are resolved without any treatment being required.

DRUG INTERACTIONS

No significant drug interactions were recorded.

RECOMMENDED DOSAGE

500 mcg/dose for 4 weeks or as prescribed by a healthcare professional.

ADMINISTRATION

While closing your mouth and taking a slow, deep breath in through your nose, it should be inhaled while simultaneously pressing the plunger firmly upward with your thumb.

CONCLUDING REMARKS

Designed to overcome the shortcomings of the oral and intramuscular formulations of vitamin B12, Cobanerve-B12 is a reliable, painless, and easy-to-administer alternative to oral and parenteral formulations of vitamin B12. It conveniently and efficiently delivers methylcobalamin (vitamin B12) for an improved patient experience.

With its intranasal administration technique, it has revolutionized drug delivery. Any patient, regardless of condition, can self-administer it; this includes individuals with malabsorption, post-bariatric surgery, pernicious anemia, nausea, or vomiting. 

REFERENCES

1) Journal of Diabetology 13(4):p 347-352, Oct–Dec 2022. 

3) Eur J Pediatr. 2020 Feb;179(2):349-352. 

2) Gastroenterology. 1997 Aug;113(2):430-3.

3) BMC Complement Altern Med. 2013; 13: 110.

4) Seth, T., et al. Int J Endocrinol Metab Disord, vol. 7, no. 1, 2021

5) Nutrients. 2020 Apr; 12(4): 1038.

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