Description

COMPOSITION: Doxycycline 100 mg + Ascorbic acid (Vitamin C) 5 ml

Doxycycline 

Drug Class: Tetracycline antibiotics  

• Tetracycline antibiotics, such as Doxycycline, could be re-purposed to eradicate Cancer Stem Cells (CSCs), in multiple cancer types including DCIS (an early form of breast cancer), ovarian, prostate, lung, and pancreatic carcinomas, as well as melanoma and glioblastoma.

• It has excellent pharmacokinetic properties, with an absorption of nearly 100% and a half-life of 18 to 24 hours.

Doxycycline + Vitamin (Ascorbic) acid

• Doxycycline and Vitamin C may represent a new synthetic lethal drug combination for eradicating CSCs, by ultimately targeting both mitochondrial and glycolytic metabolism.

• Cancer cells can escape the effects of Doxycycline, by reverting to a purely glycolytic phenotype.

• The metabolic inflexibility conferred by this escape mechanism allows Doxycycline-resistant (DoxyR) CSCs to be more effectively targeted with many other metabolic inhibitors, including Vitamin C, which functionally blocks aerobic glycolysis. 

• DoxyR CSCs are between 4- to 10-fold more susceptible to the effects of Vitamin C, inhibiting their propagation in the range of 100 to 250 µM. 

• Therefore, Doxycycline and Vitamin C may represent a new synthetic lethal drug combination for eradicating CSCs, by ultimately targeting both mitochondrial and glycolytic metabolism.